Salmon Calcitonin

Salmon Calcitonin high quality

General introduction:

Calcitonin is a 32-amino acid linear polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).It has been found in fish, reptiles, birds, and mammals. Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis.

Physiology:he hormone participates in calcium (Ca2+) and phosphorus metabolism. In many ways, calcitonin counteracts parathyroid hormone (PTH).
More specific, calcitonin affects blood Ca2+ levels in four ways:
Inhibits Ca2+ absorption by the intestines
Inhibits osteoclast activity in bones
Inhibits phosphate reabsorption by the kidney tubules
Calcitonin inhibits tubular reabsorption of Ca2+, leading to increased rates of its loss in urine.
Secretion of calcitonin is stimulated by:
an increase in serum [Ca2+]
gastrin and pentagastrin 

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